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A number of commercially available quantum computers, such as those based on trapped-ion or superconducting qubits, can now perform mid-circuit measurements and resets. In addition to being crucial for quantum error correction, this capability can help reduce the number of qubits needed to execute many types of quantum algorithms by measuring qubits as early as possible, resetting them, and reusing them elsewhere in the circuit. In this work, we introduce the idea of qubit-reuse compilation, which takes as input a quantum circuit and produces as output a compiled circuit that requires fewer qubits to execute due to qubit reuse. We present two algorithms for performing qubit-reuse compilation: an exact constraint programming optimization model and a greedy heuristic. We introduce the concept of dual circuits, obtained by exchanging state preparations with measurements and vice versa and reversing time, and show that optimal qubit-reuse compilation requires the same number of qubits to execute a circuit as its dual. We illustrate the performance of these algorithms on a variety of relevant near-term quantum circuits, such as one-dimensional and two-dimensional time-evolution circuits, and numerically benchmark their performance on the quantum adiabatic optimization algorithm (QAOA) applied to the MaxCut problem on random three-regular graphs. To demonstrate the practical benefit of these techniques, we experimentally realize an 80-qubit QAOA MaxCut circuit on the 20-qubit Quantinuum H1-1 trapped ion quantum processor using qubit-reuse compilation algorithms.