论文标题
用于改进室综合征和其他缺氧相关疾病评估的便携式氧气感应装置
Portable Oxygen-Sensing Device for the Improved Assessment of Compartment Syndrome and other Hypoxia-Related Conditions
论文作者
论文摘要
肌内氧气的测量可能在急性区室综合征的早期诊断中起关键作用，这是严重创伤后发生的一种常见疾病，导致缺血和长期后果，包括横纹肌溶解，肢体丧失和死亡。但是，迄今为止，为此目的尚无现有的氧气传感器批准。为了满足改善隔室综合征评估的需求，开发了一种用于肌内氧测量的便携式光纤装置。该设备基于磷光淬灭，其中光纤的尖端用聚（丙烯酸丙烯酸甲酯）（PPMA）（PPMA）基质覆盖，其中含有明亮发射的Pt（II） - 核卟啉。光电路电路非常便宜，基于微光谱计和带有智能手机的微控制器读数。体内止血带猪模型的结果表明，该传感器在0-880 mmHg的生理氧部分压力范围内敏感，并且表现出对肌内氧气变化的适当且可重复的响应。基于终生测量的商业实验室氧气传感器没有预期的响应。
Measurement of intramuscular oxygen could play a key role in the early diagnosis of acute compartment syndrome, a common condition occurring after severe trauma leading to ischemia and long-term consequences including rhabdomyolysis, limb loss, and death. However, to date, there is no existing oxygen sensor approved for such a purpose. To address the need to improve the assessment of compartment syndrome, a portable fiber-optic device for intramuscular oxygen measurements was developed. The device is based on phosphorescence quenching, where the tip of an optical fiber was coated with a poly(propyl methacrylate) (PPMA) matrix containing a brightly emitting Pt(II)-core porphyrin. The optoelectronic circuit is highly portable and is based on a microspectrometer and a microcontroller readout with a smartphone. Results from an in vivo tourniquet porcine model show that the sensor is sensitive across the physiological oxygen partial pressure range of 0-880 mmHg and exhibits an appropriate and reproducible response to changes in intramuscular oxygen. A commercial laboratory oxygen sensor based on a lifetime measurement did not respond as expected.
