论文标题
功能合成生物学
Functional Synthetic Biology
论文作者
论文摘要
在过去的十年中，合成生物学家在开发遗传序列模块化的方法和在各种情况下具有各种功能的工程生物系统中取得了长足的进步。但是，现场中的当前范例以使抽象变得困难，降低工程灵活性并损害可预测性和设计重用的方式纠缠序列和功能。功能合成生物学旨在通过将生物系统的设计集中在功能而不是序列上来克服这些障碍。这种重新定位将使生物设备的工程与这些设备的使用方式的细节相结合，需要概念上的和组织更改以及支持软件工具。意识到这种功能性合成生物学的愿景将使使用设备的使用方式更加灵活，重复使用设备和数据的机会，可预测性的提高以及降低技术风险和成本。
Synthetic biologists have made great progress over the past decade in developing methods for modular assembly of genetic sequences and in engineering biological systems with a wide variety of functions in various contexts and organisms. However, current paradigms in the field entangle sequence and functionality in a manner that makes abstraction difficult, reduces engineering flexibility, and impairs predictability and design reuse. Functional Synthetic Biology aims to overcome these impediments by focusing the design of biological systems on function, rather than on sequence. This reorientation will decouple the engineering of biological devices from the specifics of how those devices are put to use, requiring both conceptual and organizational change, as well as supporting software tooling. Realizing this vision of Functional Synthetic Biology will allow more flexibility in how devices are used, more opportunity for reuse of devices and data, improvements in predictability, and reductions in technical risk and cost.
