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Recommender Systems are especially challenging for marketplaces since they must maximize user satisfaction while maintaining the healthiness and fairness of such ecosystems. In this context, we observed a lack of resources to design, train, and evaluate agents that learn by interacting within these environments. For this matter, we propose MARS-Gym, an open-source framework to empower researchers and engineers to quickly build and evaluate Reinforcement Learning agents for recommendations in marketplaces. MARS-Gym addresses the whole development pipeline: data processing, model design and optimization, and multi-sided evaluation. We also provide the implementation of a diverse set of baseline agents, with a metrics-driven analysis of them in the Trivago marketplace dataset, to illustrate how to conduct a holistic assessment using the available metrics of recommendation, off-policy estimation, and fairness. With MARS-Gym, we expect to bridge the gap between academic research and production systems, as well as to facilitate the design of new algorithms and applications.