论文标题
染色质折叠以了解功能的机械建模
Mechanistic Modelling of Chromatin Folding to Understand Function
论文作者
论文摘要
实验方法已应用于解决三维染色质组织和功能方面的问题。随着数据集的大小和复杂性的增加，达到实验结果的机械解释成为一个挑战。聚合物模拟和机械模型已被应用于解释实验观察结果，以及与基因组功能不同方面的联系。在这里，我们为生物学家提供了指南，解释了不同的模拟方法及其使用的环境。
Experimental approaches have been applied to address questions in understanding three-dimensional chromatin organisation and function. As datasets increase in size and complexity, it becomes a challenge to reach a mechanistic interpretation of experimental results. Polymer simulations and mechanistic modelling have been applied to explain experimental observations, and the links to different aspects of genome function. Here, we provide a guide for biologists, explaining different simulation approaches and the contexts in which they have been used.
